According to Brembo engineers who work closely with 13 of the 14 teams in the Superbike World Championship, the Misano World Circuit Marco Simoncelli, which is 4.226 km long, falls into the category of circuits that are moderately demanding on brakes. On a scale from 1 to 5, it has earned a difficulty index of 3 despite having 11 braking points per lap for a total brake usage time of 27.3 seconds. Three braking points are classified as High, 5 as Medium, and 3 as Light.

Nicolò Bulega's victory in the Superpole Race of the Aragon round marked the 150th win by an Italian rider in the Superbike World Championship. This achievement has been contributed to by 16 different riders, but so far only one has been crowned world champion: Max Biaggi, who won 21 races in Superbike and became a two-time world champion in 2010 and 2012 with the Aprilia RSV4 1000 equipped with Brembo braking systems. Fourteen years later, Italy might have found his successor, once again supported by Brembo brakes.

Since his debut in the Superbike World Championship in 2024, Nicolò Bulega has been using the Brembo index master cylinder to control the rear brake both during braking and acceleration, through a control located on the left side of the handlebar. Compared to the thumb master cylinder, the setup is different, with a 180-degree rotation, although the purpose remains the same: to enhance modulation during deceleration as well as corner exit, allowing for quicker cornering.

The first Italian to triumph at Misano in the Superbike World Championship was Giancarlo Falappa: in 1993, the "Lion of Jesi" claimed pole position and won both races, also setting the fastest laps in each. Thanks to that double victory, the Italian rider took the lead in the standings with a 4-point advantage over Scott Russell, but he would hold onto the lead only until Austria. His Ducati 888 was equipped with Brembo carbon discs, which would be banned at the end of 1994 in favor of the more economical steel.