The first Aprilia motorcycle equipped with the 1078 cc V4 engine, the RSV4 1100 Factory constitutes the evolution of the RSV4 philosophy, the premium range born out of the bike by the same name that won 7 World Superbike Championships. The use of the carbon fins, titanium for the exhaust terminal and aluminum alloy forged wheels allowed the Aprilia engineers to keep the bike's curb weight with a full tank of fuel below 440 lbs. Thanks to the increased bore compared to the 1000 V4, the optimized intake valve timing and longer fifth and sixth gear ratios, the power comes in at 217 HP and maximum torque is 122 Nm at 11,000 rpm. Aprilia confirms its racing DNA.

​In addition to the engine aspects, the RSV4 1100 Factory is also evolved in terms of chassis architecture, thanks to the association with Brembo. On the front, it uses a double 330 mm floating disc with stainless steel braking band and aluminum flange with 6 drag points. These are gripped by radial-mounted monobloc Stylema™​ calipers with 4 opposed 30 mm pistons. These have two raised ribs that serve a dual purpose: they are structural elements, but also design elements that contribute to the air intake that is linked to the upper ribbing thanks to the two edges. The radial master cylinder is also Brembo, as is the rear caliper with 2 isolated 32 mm pistons.