Moving up to 250 at the end of 1997, Valentino was one of the first to test the radial mount calipers that Brembo had made based on input from Aprilia: the manufacturer from Noale was constantly looking for technical solutions that would give them an advantage over their adversaries.
The success of the radial calipers (Loris Capirossi 250 world champion in 1998) led to it being used in 500 as well, where Rossi arrived in 2000 after having won the World Championship. Already familiar with them from his Aprilia days, he had no trouble adapting and within a few months he began to dominate.
Marc Marquez began using radial calipers from the start, at least on the front, because in 125 and Moto2, the rear calipers were axial. Speaking of front calipers, however, Marquez has won in MotoGP with both aluminum-lithium calipers, used until 2015, and with aluminum-only calipers, mandatory in recent years.
However, Marquez was the first rider to have won a 500-MotoGP race using carbon (Brembo) discs in the wet: the Spaniard accomplished the feat at the GP of San Marino on 10 September 2017, finishing ahead of the Ducatis ridden by Andrea Dovizioso and Danilo Petrucci that mounted steel discs.