The limits of MotoGP are essentially two:
1) The time required to reduce speed when facing a curve
2) Speed while in a curve
Both are attributable to several factors mainly including:
A) the different dynamics of the two vehicles, where MotoGP must take into account the tilt limit of the vehicle.
B) the substantial difference due to the aerodynamic load, non-existent on a MotoGP bike, but heavily influencing the deceleration values of an F1 car.
C) the significant difference of the footprint left by the tires of both vehicles.